There is evidence to suggest that the expression and activity of Corin is decreased in the development and progression of HF, (Chen et al., 2010; Dong et al., 2010; Ibebuogu et al., 2011; Tripathi et al., 2016) resulting in dysregulated proANP processing and less biologically active ANP in the circulation. Here, NPPA is linked to hydrops fetalis.