ACTA1 and hypertensive disorder: Acta1 is involved in the pathological progression of myocardial remodeling (Pagano et al., 2017; Cañes et al., 2020), which is closely related to the prognosis of HTN and HFpEF (Fortuño et al., 2001; Georgiopoulou et al., 2010; Heinzel et al., 2015).