ACTA1 and hypertensive disorder: Acetyl-CoA acetyltransferase, mitochondrial (Acta1; degree = 38), glycogen synthase kinase 3 beta (Gsk3b; degree = 33), 2,4-dienoyl-CoA reductase 1 (Decr1; degree = 28), myosin heavy chain 7 (Myh7; degree = 28), and actinin alpha 2 (Actn2; degree = 26) were identified as hub proteins in the HTN-DEP PPI network (Figure 7F).