Several studies have shown that the expression of Tf and Prnp is altered in many cardiovascular diseases and that Tf and Prnp may be novel biomarkers for HTN and HFpEF (Gao et al., 2013; Rahim et al., 2018; Roura et al., 2018; Pang et al., 2020). Here, PRNP is linked to cardiovascular disorder.