Importantly, we found that treatment with TMAO inhibitor DMB attenuated circulating TMAO levels, prevented the exacerbations in LVFS, LVESV, LVEDV, levels of serum creatinine, urinary KIM-1 creatinine clearance and proteinuria in MI + STNx rats at week 14. Here, HAVCR1 is linked to myocardial infarction.