HAVCR1 and Abnormal renal physiology: In agreement with previous study (Savira et al., 2020b), our results showed that MI + STNx rats exhibited impaired cardiac function and remodeling as indicated by reduced LVEF and LVFS and increased LVESV and LVEDV, and renal dysfunction as evidenced by increased levels of serum creatinine and urinary KIM-1 and decreased creatinine clearance at week 6.