NLRP3 and early-onset autosomal dominant Alzheimer disease: Moreover, NLRP3 inflammasome activation is conducive to the evolution of many other medical conditions, including Parkinson's disease (Han et al., 2019), inflammatory bowel disease (Chen et al., 2021), Alzheimer’s disease (Feng et al., 2020), Crohn’s disease (Zhang G. et al., 2021), and liver disease (Yang et al., 2020).