Intraperitoneal injection of lipopolysaccharide induces sepsis (Ulevitch and Tobias, 1995; Liao et al., 2018), and the activation of the NLRP3 inflammasome plays a crucial role in vivo, accompanied by the production of IL-1β and the occurrence of inflammation (Lee et al., 2017; Xiong et al., 2020). The gene discussed is IL1B; the disease is Sepsis.