CASP3 and neoplasm: We also found that the expression of cleaved caspase-3 in cotreatment group tumor tissues was significantly upregulated (HCT116: 11.36-fold compared with propranolol treatment, p < 0.001; HCT116: 2.68-fold compared with T1012G treatment, p < 0.01; MC38: 7.88-fold compared with propranolol treatment, p < 0.01; MC38: 2.51-fold compared with T1012G treatment, p < 0.05; Figures 5I–L).