For example, the research on TMB is only based on dMMR and MSI-H patients (Schrock et al., 2019; Loupakis et al., 2020), and there is no difference in immune spectrum between tumor cells and tumor-infiltrating lymphocytes (TILs) between POLE-MT and POLE-WT (Ahn et al., 2016). Here, POLE is linked to neoplasm.