According to the KEGG results, several classical pathways, such as PI3K-Akt signaling pathway (Shi et al., 2019), NF-κB signaling pathway (Ju et al., 2018), cytokine-cytokine receptor interaction (Gouda and Bhandary, 2019), mitophagy-animal (Zhang et al., 2020), TGF-β signaling pathway (Liu et al., 2018) and complement and coagulation cascades (Chimenti et al., 2017), were regarded as the potential targets of LHQW for treating LPS-induced ALI. Here, AKT1 is linked to acute respiratory distress syndrome.