Lamin A is a regulator of Sirt6 functions in DSBs repair. Lamin A interacts with Sirt6, activating it and facilitating its localization in damaged DNA. Lamin A promotes Sirt6-mediated recruitment of DNA-PK, CtIP deacetylation, and PARP1 poly-ADP ribosylation. Laminopaties, like Hutchinson-Gilford progeria syndrome, may impair Sirt6 function, and induce aging by DNA damage accumulation. Here, PRKDC is linked to Hutchinson-Gilford progeria syndrome.