Second, we identified 1 novel pathogenic variant in SQSTM1 genes, 3 novel likely pathogenic variants in ABCA7, ATP13A2, and NOS3, and 21 variants with uncertain significance in PSEN2, C9orf72, NOTCH3, ABCA7, ERBB4, GRN, MPO, SETX, SORL1, NEFH, ADCM10, and SORL1, etc., in patients with AD or FTD. The gene discussed is PSEN2; the disease is Alzheimer disease.