SHANK3 and autism: In addition, we investigated whether spontaneous USVs are perturbed in mice lacking Shank3, a glutamatergic synaptic scaffolding protein that we previously associated with autism (Durand et al., 2007; Leblond et al., 2014; deletion of exon 11; Schmeisser et al., 2012; Vicidomini et al., 2017).