Since single-nucleotide polymorphisms in the galectin-3-encoding LGALS3 gene being associated with an increased risk of AD and galectin-3 deletion decreasing Aβ burden in 5xFAD mice, whereas injected galectin-3 promotes aggregation of insoluble Aβ, galectin-3 may accelerate AD progression (Boza-Serrano et al., 2019). The gene discussed is LGALS3; the disease is Alzheimer disease.