HFD consumption increases the expression of Myd88, an adaptor molecular of TLR signaling, in hypothalamic astrocytes; astrocyte-specific deletion of Myd88 ameliorates hypothalamic reactive gliosis and inflammation and prevents obesity in HFD fed mice (Jin et al., 2020). This evidence concerns the gene MYD88 and obesity due to melanocortin 4 receptor deficiency.