The knockdown of TDP-43, a protein implicated in amyotrophic laterals sclerosis (ALS) (Sreedharan et al., 2008), decreases the number and motility of Rab-11 endosomes which in turn impairs AMPAR recycling (Esteves da Silva et al., 2015; Schwenk et al., 2016). The gene discussed is RAB11A; the disease is amyotrophic lateral sclerosis.