GRIN2A and epilepsy: Previously, 10 GRIN2A mutations with epilepsy were identified as GOF through two-electrode voltage clamp recordings (Endele et al., 2010; Lemke et al., 2013; Yuan et al., 2014; Swanger et al., 2016; Chen et al., 2017; Ogden et al., 2017; Xu et al., 2018).