Similar to our results, Pdha1 knockout tumor cells show an increase in extracellular acidification rate, an increase in extracellular lactate levels, and a decrease in ATP production, indicating that Pdha1-deleted cells cannot perform normal mitochondrial oxidative phosphorylation but are forced to undergo glycolysis (Zhong et al., 2017; Liu et al., 2019). The gene discussed is PDHA1; the disease is neoplasm.