HMOX1 and Parkinson disease: The mechanisms by which TQ delays neurodegeneration have been clearly elucidated in Parkinson’s disease: it reduces dopaminergic impairment switching on the Nrf2/ARE signaling cascade that triggers the activation of antioxidant genes including Heme Oxygenase 1 (HO-1), Quinone Oxidoreductase (NQO1) and Glutathione-S-Transferase (GST) (Dong et al., 2021).