In a multi-centre prospective study, Mearelli et al. developed a predictive algorithm incorporating age, SOFA score, recent antimicrobial therapy, hyperthermia and a biomarker panel (white blood cell, CRP, PCT, presepsin, soluble phospholipase A2 group IIA & soluble interleukin-2 receptor α) which demonstrated an high negative predictive value for ruling out sepsis in the Emergency Department [108]. Here, CALCA is linked to Sepsis.