In a prospective study of 1572 patients presenting to the Emergency Department, Ljungstrӧm et al. found neutrophil to lymphocyte count ratio to be superior to PCT and CRP for the diagnosis of bacterial sepsis (AUROC 0.68 vs 0.64 vs 0.57, p < 0.05) and the diagnosis of bacterial infection, although the difference in AUROC did not reach statistical significant in the latter [34]. This evidence concerns the gene CALCA and bacterial infectious disease with sepsis.