For patients with osteosarcoma, meta-analysis performed in this paper demonstrated that high great contents of NLR, CRP, and GPS before treatment may be a negative prognostic element, and ethnicity, histology, and metastasis all have an impact on its prognosis of patients with osteosarcoma; however, PLR and LMR might have nothing to do with it. This evidence concerns the gene CRP and osteosarcoma.