Among the 112 significantly (P < 0.05) over‐expressed miRNAINV target genes, 41 (36.6%) genes were discovered to be significantly elevated (P < 0.05) in the leading edges of patient GBM tumors found in the IVY project, including the KCNA1, which was 1.54‐fold (GBMINV/GBMTC) in the PDOX and 4.79‐fold in the leading edges of patient tumors (group 1 in Table S5, Supporting Information). Here, KCNA1 is linked to glioblastoma.