We first intended to functionalize the protein dendrimers for tumor‐cell targeting, and employed an epidermal growth factor receptor (EGFR)‐specific repebody which was previously developed from a non‐antibody protein scaffold.[35, 36] For a simple and general functionalization process, a conjugation module comprising of a tandem of SpyTag and SnoopTag was genetically fused to the C‐terminal of the repebody using a flexible linker for optimal exposure to yield Tmono (indicating a conjugation module‐fused targeting moiety) (Figure 2a). Here, EGFR is linked to neoplasm.