NFE2L2 and cancer: Recently, several studies proposed potential mechanisms underlying the longevity and cancer resistance of NMRs involving protein stability [7], activity of nuclear factor, erythroid 2-like 2 (NRF2) signaling [8], translational fidelity [9], production of high molecular mass hyaluronic acid [10], the unique cellular response to reprogramming/oncogenic stress [11, 12], and the retrotransposon [13].