The Gln allele of the CREBRF p.Arg457Gln variant associates with increased BMI but reduced risk of diabetes [34], the Ser allele of the IL37 p.Asn182Ser variant with gout [43], and the Western Polynesian-specific Leu allele of the ABCC4 p.Pro1036Leu variant with gout [44]. This evidence concerns the gene CREBRF and diabetes mellitus.