As transcription factors, MYB family members, that is, A-MYB, B-MYB, and C-MYB, are highly expressed in multiple malignancies such as non-small cell lung cancer, colon cancer, and hepatocellular carcinoma [22–24], with key roles in cell proliferation [25], cell cycle regulation [26], apoptosis, and tumor progression [27]. Here, MYBL2 is linked to malignant colon neoplasm.