TNF and periodontitis: In innate immune responses, neutrophils and macrophages by producing different types of inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α), interleukin 1β (IL‐1β), IL‐8 and monocyte chemoattractant protein 1 (MCP‐1) as well as by secreting several tissue‐degrading enzymes such as collagenases and matrix metalloproteinases (MMPs) play fundamental roles in the initiation of the periodontitis.7