Accordingly, cell type–specific lung tumor models have been generated by utilizing either club cell‐specific CCSP‐Cre‐ or type II epithelial cell–specific SPC (surfactant protein C)‐Cre–mediated expression of oncogenes (e.g. Kras) or deletion of tumor suppressors (e.g. Trp53 and Pten) [51]. The gene discussed is TP53; the disease is neoplasm.