CD274 and neoplasm: The spleen, blood, and tumor uptakes of 111In-DTPA-anti-PD-L1 were significantly altered (that of spleen reduced, and those of blood and tumor increased) in the presence of excess (30- or 100-fold) unlabeled anti-PD-L1 mAb (compared with the unblocked control group, P ≤ 0.0002 for spleen and blood and P ≤ 0.05 for the tumor in the blocked group) [15].