CD274 and neoplasm: In a study of the PD-L1 targeting tracer 64Cu-WL12, the imaging and biodistribution data showed high uptake in the tumor after pretreatment with low doses (0.06 mg/kg) of the anti-PD-L1 mAb (atezolizumab whose binding interface on PD-L1 overlaps with WL12), compared to that at the higher doses of the mAb (0.6 and 3.6 mg/kg) [16].