Transferrin (Tf1 – AAEL015458), found to be under expressed in temephos resistant larvae in the current study, also has roles in the innate immune response to arbovirus infection (Wessling-Resnick 2018, Licciardi et al. 2020) and has previously been reported to be down regulated in CHIKV and DENV infected mosquitoes which may favor viral replication (Tchankouo-Nguetcheu et al. 2010). The gene discussed is TF; the disease is arbovirus infection.