Studies in Drosophila have clarified that of Ataxin-2’s multiple activities, its specific role in RNP-granule assembly contributes to the progression of neurodegenerative phenotypes in fly models of ALS/FTD (Elden et al. 2010; Bakthavachalu et al. 2018). The gene discussed is RNPC3; the disease is frontotemporal dementia.