ATXN2 and amyotrophic lateral sclerosis: Thus, knockdown of Ataxin-2 via antisense oligonucleotides delays the maturation and recruitment of TDP-43 to RNP granules (stress granules) in vitro, reduces pathologies and extends lifespans in a TDP-43 mouse model of ALS (Becker et al. 2017; Scoles et al. 2017).