Thus, genetic deletion of a C-terminal intrinsically disordered region (cIDR) required for efficient formation of RNP granules results in perfectly viable adult flies, which, remarkably, show resistance to cytotoxicity in two Drosophila ALS models, of C9ORF72 and FUS, respectively (Bakthavachalu et al. 2018). Here, FUS is linked to amyotrophic lateral sclerosis.