The intracellular location of such inclusions can vary: for instance, in SCA-3, neuronal inclusions of Ataxin-3 are mostly nuclear, while in SCA-2 inclusions of Ataxin-2 are mainly cytoplasmic (Huynh et al. 2000; Seidel et al. 2017). This evidence concerns the gene ATXN2 and spinocerebellar ataxia type 2.