However, compared with cells co-transfected with miR-inhibitor and shRNA-NC, the growth of cells co-transfected with miR-338-3p-inhibitor and shRNA-CHL1 was significantly reduced, indicating that while the inhibition of miR-338-3p promoted the growth of tumor cells, these effects were partially reserved after CHL1 knockdown (Fig. 4G: A549: P < 0.001, Fig. 4H: SK-MES-1: P < 0.001). This evidence concerns the gene CHL1 and neoplasm.