CHL1 and non-small cell lung carcinoma: Besides, Fig. 6J, K showed that the levels of CHL1 mRNA and protein were significantly inhibited in cells co-cultured with exosomes with miR-338-3p mimics than those in cells co-cultured with exosomes with miR-338-3p mimics-NC (Fig. 6J: P < 0.001, Fig. 6K: P < 0.001), further demonstrated that exosomal miR-338-3p could reduce the expression of CHL1 in NSCLC.