CHL1 and neoplasm: However, compared with cells co-transfected with miR-inhibitor and shRNA-NC, the growth of cells co-transfected with miR-338-3p-inhibitor and shRNA-CHL1 was significantly induced, indicating that while the inhibition of miR-338-3p suppressed the apoptotic rates of tumor cells, these effects were partially reserved after CHL1 knockdown (Fig. 4I: A549: P < 0.001, Fig. 4J: SK-MES-1: P < 0.05).