We additionally identified and analyzed multiple immune-cell subpopulations in T, B lymphocytes, dendritic cells (DC), and monocytes in PBMCs from patients via scRNA-seq and found there was an obvious imbalance of these subsets under SLE condition and a high correlation with KAT2A, cGAS, and STING. Here, STING1 is linked to systemic lupus erythematosus.