We observed that overexpression of FBXL10 could reduce the expression of E-cadherin (Fig. 2F), and bioinformatics analysis from TCGA datasets showed that the expression of FBXL10 was negatively associated with CDH1 in breast cancer (Fig. S1B), so it provoked our thinking that whether FBXL10 could repress the expression of E-cadherin and further modulate EMT process. The gene discussed is CDH1; the disease is breast cancer.