Kottakis et al. and our previous research demonstrated that FBXL10 served as an oncogene to promote the self-renewal and proliferation of breast cancer cells via regulating multiple factors including miRNAs/PRC1/PRC2 axis and estrogen-related receptor α (ERRα)/peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC1-β) signaling [43, 44]. The gene discussed is ESRRA; the disease is breast cancer.