PRKN and Parkinson disease: While PD patients with GBA mutations show extensive α-Syn-positive LB pathology, those with bi-allelic mutations in parkin or PINK1 show nigral degeneration without LB, whereas those carrying LRRK2 mutations show LB pathology in most cases, but also misfolded tau deposition or nigral degeneration without LB pathology [4, 29].