Consistent with this interpretation is the finding that DLB patients carrying GBA mutations, who were all positive by α-Syn RT-QuIC, showed normal mean CSF profile of t-Tau, p-Tau and Aβ1–42, whereas the group of sporadic DLB patients without GBA mutations presented higher mean CSF levels of t-Tau, p-Tau and NfL as well as reduced Aβ1–42 levels indicating a typical Alzheimer’s disease profile. The gene discussed is NEFL; the disease is early-onset autosomal dominant Alzheimer disease.