The FH mutation of mitochondrial enzyme induces enhanced carcinogenic risk in renal carcinoma and leiomyosarcoma, SDH mutation induces carcinoma in neuroblastoma, and IDH causes malignant cancers like glioma, myeloid neoplasia, chondrosarcoma, and cholangiocarcinoma [66–68]. The gene discussed is SDHB; the disease is carcinoma.