However, mitophagy can provide nutrients for cancer cells by degrading organelles and then promotes tumor growth, since the mitophagy regulators of cancer cells comprise a various of constituents that regulate stress response, cell cycle, survival pathway and ECM detachment during carcinoma proliferation and metastasis, such as AMPK, FOXOs, Sirtuins, ATF4/5 [71]. This evidence concerns the gene ATF4 and neoplasm.