Glycolysis regulating factors, such as hypoxia-inducible factor-1 (HIF-1), phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/ mTOR), involve the switch of the glycolytic pathway, contributing to cancer proliferation and metastasis [28, 29]. Here, AKT1 is linked to cancer.