A comparison of genotype and allele frequencies of VEGF SNPs in controls versus endometriosis patients with ascites did not show statistically significant differences; the minor allele frequency of − 460T > C, − 1154G > A, + 936C > T and + 2578C > A were 24%, 8%, 6% and 10% in the control group and 5%, 5%, 1% and 4% in endometriosis patients with ascites, respectively (p > 0.05). The gene discussed is VEGFA; the disease is endometriosis.