Patients with inactive chronic HBV infection, as indicated by HBeAg-negative, HbeAb-positive, persistently normal ALT, and a low viral load of < 2000 IU/mL, have an excellent long-term prognosis with low rates of histological progression, high rates of HbsAg clearance, and a very low risk of cirrhosis and HCC [15]. This evidence concerns the gene GPT and hepatocellular carcinoma.