CCL2 and cervical cancer: For example, Pedraza-Brindis et al. reported that the supernatant of cervical cancer cells down-regulated the phosphorylation of NF-κB-p65 and STAT1 in M1 macrophages and induced a stable M2 phenotype, accompanied by increased expression of IL-10, IL-6, CCL2, IL-8, GM-CSF, G-CSF, platelet-derived growth factor (PDGF) AA and PDGF-BB [40, 41].