A few ideally designed BsAbs have been developed, such as IBI322 for CD47/PD-L1, IMM0306 for CD47/D20 and IMM2902 for CD47/Her2, which can preferentially bind to CD47 on tumor cells with the help of higher affinity of the bi-specific molecules for another tumor target, effectively inhibiting CD47-SIRPα signal and triggering strong tumor cell phagocytosis in vitro, but only with minimal impact on CD47 single positive cells such as human RBCs. This evidence concerns the gene CD274 and neoplasm.