Among them, the single drug approach is mainly for AML and some solid tumors, the combination with azacitidine for the first-line treatment of AML and MDS, the combination with therapeutic antibody for recurrent or refractory non-Hodgkin's lymphoma (R/R NHL) and the combination with immunotherapy PD-1/PD-L1 (avelumab) for ovarian cancer [12]. The gene discussed is CD274; the disease is acute myeloid leukemia.