In addition, these preliminary efficacy data from the SRI cohort represent an advancement in either CR rate and/or sustained PFS compared to recent treatment options for patients with relapsed/refractory MCL, including the BTK inhibitors zanubrutinib (68.6% CR rate; 22.1 months median PFS) [18] and acalabrutinib (43% CR rate; 20 months median PFS) [19] or KTE-X19 (anti-CD19 chimeric antigen receptor T-cell therapy; 67% CR rate; median PFS not reached at 12.3 months of follow-up) [20]. This evidence concerns the gene BTK and mantle cell lymphoma.