Based on cutoff values of hsa_circ_0140271 expression, there was no difference in those factors level between hsa_circ_0140271 positive and negative group among female RA patients, but it was observed IL-6, IL-8 and TNF-α levels were higher in the hsa_circ_0140271 positive group when calculating female RA patients and female healthy subjects together. This evidence concerns the gene TNF and rheumatoid arthritis.