CD274 and neoplasm: Furthermore, TB/PTX@RTK micelle-mediated chemo-PDT elicited anti-tumor immune response and upregulated the expression of PD-L1 on tumor cell surface, which could effectively synergize with anti-PD-L1 monoclonal antibodies to induce abscopal effect, and establish long-term immunological memory to inhibit tumor relapse and metastasis.