The cRGD peptide is coupled with NHS-PEG-TK-PLGA through an amidation reaction, and then through the self-assembly of cRGD-PEG-TK-PLGA and PEG-TK-PLGA, excellent tumor targeting can be obtained on the prepared micelles of cRGD-modified PEG-TK-PLGA (RTK) [31, 32]. This evidence concerns the gene TKT and neoplasm.