CD8A and metastatic malignant neoplasm in the lymph nodes: Univariate analysis showed that significant predictors of OS were PD-1+ CD8 T cells (P = 0.027) and lymph node metastasis (P = 0.031), and significant predictors of DFS were PD-1+ CD8+ T cells (P = 0.023) and lymph node metastasis (P = 0.033) (Table 2).