Conversely, etoposide used for the treatments of lung, testicular and ovarian cancer, lymphoma, leukemia, and neuroblastoma, and cytarabine used to treat acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and non-Hodgkin’s lymphoma promote nSMase activation, leading to reduced surface membrane SM content and Cer accumulation [46, 47, 69]. The gene discussed is SMPD2; the disease is leukemia.