An integrated Nomogram was further constructed by combining the 25-lncRNA signature, AFP, VI and TNM with a C-index 0.739 (Fig. 5E), and the calibration curves of the integrated nomogram for 1-year and 2-year DFS were presented in Fig. 5F. Therefore, the combination of the 25-lncRNA risk signature with AFP, TNM and VI could improve the prognosis evaluation for HCC early recurrence. The gene discussed is AFP; the disease is hepatocellular carcinoma.