We demonstrated that the 25-signature risk score significantly and negatively associate with intratumor accumulation of type 1 T helper cell, effector memory CD8 T cell and activated CD8 T cell, which are well-known antitumor immune cells involved in cancer immune therapy [73–75], further suggesting that this 25-lncRNA signature has potential to predict the post-surgery prognosis in HCC patients. Here, CD8A is linked to cancer.