An SVM classifier was established based on 41 genes involved in cytokine-cytokine receptor interaction (CXCL1, CCR2, IL1B, and IL1A), ECM-receptor interaction (COL4A2, COL4A1, COL6A3, COL3A1, and COL1A2), pathways in cancer (STAT5A and SP11), and leukocyte transendothelial migration and chemokine signaling pathway (ITK). The gene discussed is COL1A2; the disease is cancer.