For instance, use implanted 3D-Printed vertebral bodies with robotic stereotactic radiotherapy for spinal tumor treatment [13]; encapsulate irinotecan (CPT-11) into micelle-based nanoparticles for a better efficacy in cancer therapy [14]; immunotherapy using immune checkpoint inhibitors has been applied in several solid tumors including TNBC [15, 16]; development of allele-specific K-RasG12C inhibitors for the treatment of oncogenic KRAS mutant in different cancer types [17]. Here, KRAS is linked to cancer.