Chuan He et al. reported a novel immune evasion mechanism in Nature that the N6-methyadenosine (m6A) marked transcripts encoding lysosomal proteases were recognized and bounded by YTHDF1 in DCs, which promoted translation of lysosomal proteases for excessive neoantigen degradation, thereby mitigating neoantigen-specific tumor immunity. This evidence concerns the gene YTHDF1 and neoplasm.