The TAS2Rs with highest expression in HNSCC (TAS2R4, TAS2R14, TAS2R19, TAS2R20, TAS2R30, TAS2R43, and TAS2R45) overlap with TAS2Rs expressed at increased levels in breast cancer [20, 21]. The gene discussed is TAS2R43; the disease is head and neck squamous cell carcinoma.