Firstly, homozygous mutations of the astroglial eaat2a in zebrafish resemble a form of DEE present in human epilepsy patients with de novo mutations in the orthologous gene (EAAT2 = SLC1A2) (Epi4K Consortium et al., 2013; Epi4K Consortium, 2016; Guella et al., 2017). Here, SLC1A2 is linked to epilepsy.