However, previous studies showed that CpG island hypermethylation of the TAZ promoter exists in proneural (PN) but not MES GBM.[11] This is consistent with increased expression of TAZ in MES GBM and enhanced activity of the TAZ‐TEAD transcriptional machinery.[11, 13] Nonetheless, whether any other mediators are involved in the transcriptional regulatory machinery for MES GBM remains elusive. This evidence concerns the gene WWTR1 and glioblastoma.