OLIG2 and Machado-Joseph disease: Furthermore, in protein analyses for the oligodendrocyte transcription factor OLIG2 and MBP in cerebellar brain samples of SCA3 patients and healthy controls (Fig. 8C) we observed a tendency towards a reduction of OLIG2 and a significant reduction for MBP (Note: the second control was not considered for quantification to avoid overinterpretation of the data).