In addition, Kdm6b is also involved in maintaining the pluripotency of mouse embryonic stem cells, assisting the self-renewal and differentiation of cardiovascular cells, and skin repairment (Agger et al. 2009; Apostolou and Hochedlinger 2013; Ohtani et al. 2013; Shaw and Martin 2009), immune system (De Santa et al. 2007; Liu et al. 2015; Salminen et al. 2014; Yan et al. 2014), neurodegenerative disease (Gomez-Sanchez et al. 2013; Tang et al. 2014), and cancer (Anderton et al. 2011; Ramadoss et al. 2012; Wei et al. 2013). The gene discussed is KDM6B; the disease is neurodegenerative disease.